The Basis of Oncoimmunology.
Cell. 2016; 164: 1233-1247
Distinct role of macrophages in different tumor microenvironments.
Cancer Res. 2006; 66: 605-612
Myeloid cells in hepatocellular carcinoma.
Hepatology. 2015; 62: 1304-1312
Tumour-associated macrophages as treatment targets in oncology.
Nat Rev Clin Oncol. 2017; 14: 399-416
Targeting Macrophages in Cancer: From Bench to Bedside.
Front. Oncol. 2018; 8: 49
Understanding the Origin and Diversity of Macrophages to Tailor Their Targeting in Solid Cancers.
Front Immunol. 2019; 10: 2215
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.
Blood. 2004; 104: 2224-2234
Origin of monocytes and macrophages in a committed progenitor.
Nat. Immunol. 2013; 14: 821-830
Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages.
Immunity. 2016; 44: 755-768
Beyond stem cells: self-renewal of differentiated macrophages.
Science. 2013; 342: 1242974-1242981
MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages.
Science. 2009; 326: 867-871
The cellular and molecular origin of tumor-associated macrophages.
Science. 2014; 344: 921-925
IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.
J. Pathol. 2015; 235: 698-709
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation.
Science. 2011; 332: 1284-1288
Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Nat. Med. 2013; 19: 1166-1172
Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury.
Cell Rep. 2016; 16: 605-614
CD169 identifies an anti-tumour macrophage subpopulation in human hepatocellular carcinoma.
J. Pathol. 2016; 239: 231-241
Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes.
Blood. 2007; 110: 587-595
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.
J Mol Med. 2014; 92: 1283-1292
Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Sci Transl Med. 2015; 7: 277ra30
Adenosine receptors in regulation of dendritic cell differentiation and function.
Blood. 2008; 112: 1822-1831
Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs.
Clin Cancer Res. 2013; 19: 5626-5635
Global cancer statistics, 2012.
CA Cancer J Clin. 2015; 65: 87-108
Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis.
J Clin Invest. 2018; 128: 3425-3438
The human heart contains distinct macrophage subsets with divergent origins and functions.
Nat Med. 2018; 24: 1234-1245
Targeting immunosuppressive adenosine in cancer.
Nat. Rev. Cancer. 2017; 17: 709-724
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.
Nat. Immunol. 2017; 18: 1332-1341
Targeting A2 adenosine receptors in cancer.
Immunol. Cell Biol. 2017; 95: 333-339
Adenosine signaling promotes regeneration of pancreatic β cells in vivo.
Cell Metab. 2012; 15: 885-894
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Nat Commun. 2017; 8: 584
Targeting Cancer-Derived Adenosine:New Therapeutic Approaches.
Cancer Discov. 2014; 4: 879-888
Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.
Proc. Natl. Acad. Sci. U.S.A. 2013; 110: E2191-2198
Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.
Cell. 2018; 175: 400-415.e13
Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma.
J Hepatol. 2019; 71: 333-343
Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer.
Cancer Immunol Res. 2019; 7: 1605-1618
Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity.
Breast Cancer Res. Treat. 2011; 130: 635-644
The prognostic implications of macrophages expressing proliferating cell nuclear antigen in breast cancer depend on immune context.
PLoS ONE. 2013; 8e79114
Macrophage diversity enhances tumor progression and metastasis.
Cell. 2010; 141: 39-51
Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.
Cell Metab. 2014; 19: 162-171
4-1BBL signaling promotes cell proliferation through reprogramming of glucose metabolism in monocytes/macrophages.
FEBS J. 2015; 282: 1468-1480
Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.
J. Clin. Invest. 2017; 127: 2842-2854
Tumour-educated macrophages promote tumour progression and metastasis.
Nat. Rev. Cancer. 2004; 4: 71-78
Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment.
Front Immunol. 2016; 7: 109
Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer.
J Mol Med. 2013; 91: 147-155
Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists.
Cancer Immunol Res. 2014; 2: 598-605
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Immunity. 2017; 47: 323-338.e6
Macrophages as regulators of tumour immunity and immunotherapy.
Nat Rev Immunol. 2019;