We studied the pathological consequence of long-term hypercholanemia caused by NTCP deficiency, and found that NTCP deficiency leads to gallbladder abnormalities in both mice and humans, thereby pointing to a potentially underappreciated cause for gallbladder diseases encountered by physicians in the clinic.
NTCP (sodium taurocholate co-transporting polypeptide), HBV (hepatitis B virus), HDV (hepatitis D virus), CSI (cholesterol saturation index), Fgf15 (fibroblast growth factor 15), FGF19 (Fibroblast Growth Factor 19), WT (wild-type), TBA (total bile acids)
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We thank our patients for their participation in this study. This work was supported by the National Natural Science Foundation of China to WL (81525018) and J-SW (81570468); the Science and Technology Major Project of Beijing to WL (D171100003117003); the Shanghai Medical Key Subject Construction Project to J-SW (ZK2015A04); and the Science and Technology Bureau of the Beijing Municipal Government to WL and JS.
Conﬂicts of interest
The authors disclose no conﬂicts of interest.
© 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.
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