CD (Crohn’s disease), HDAC (histone deacetylases), H3K27ac (histone-3 lysine 27 acetylation), IBD (inflammatory bowel disease), DSS (dextran sulphate sodium), VPA (valproic acid)
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CF and AL are joint first authors
Author contributions: CF, AL and AR performed experiments and analysed data; CF conducted patient identification, sample collection and clinicopathological data acquisition; RF carried out histological analysis; MPC designed animal experimentation and acquired data; CF, AL, AA, JOL and AS designed the study and obtained funding; AL and AS wrote the first draft of the manuscript and all authors read and approved the manuscript.
Conflicts of interest: The authors disclose no conflicts
Funding: This work was supported by European Crohn’s and Colitis Organisation (Fellowship award 2015 to CF), Rosetrees Foundation (research grant CM550 to CF and AS) The Barts Charity (research grant MGU0399 to AS and JOL).
© 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.
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