Keywords
Abbreviations:
CD (Crohn’s disease), HDAC (histone deacetylases), H3K27ac (histone-3 lysine 27 acetylation), IBD (inflammatory bowel disease), DSS (dextran sulphate sodium), VPA (valproic acid)
Article Info
Publication History
Accepted:
November 12,
2020
Received in revised form:
October 16,
2020
Received:
July 24,
2020
Publication stage
In Press Journal Pre-Proof
Footnotes
CF and AL are joint first authors
Author contributions: CF, AL and AR performed experiments and analysed data; CF conducted patient identification, sample collection and clinicopathological data acquisition; RF carried out histological analysis; MPC designed animal experimentation and acquired data; CF, AL, AA, JOL and AS designed the study and obtained funding; AL and AS wrote the first draft of the manuscript and all authors read and approved the manuscript.
Conflicts of interest: The authors disclose no conflicts
Funding: This work was supported by European Crohn’s and Colitis Organisation (Fellowship award 2015 to CF), Rosetrees Foundation (research grant CM550 to CF and AS) The Barts Charity (research grant MGU0399 to AS and JOL).
Identification
DOI: https://doi.org/10.1016/j.jcmgh.2020.11.009
Copyright
© 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.
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