Home Journals CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing

CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing

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CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing

It is crucial that we understand how mucosal healing is regulated because it predicts sustained remission and resection-free survival in patients with IBD.4x4Neurath, M.F. Current and emerging therapeutic targets for IBD. Nate Rev Gastroenterol Hepatol. 2017;
14: 269
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The renewal of the intestinal epithelium is critical for mucosal healing and is regulated by signaling pathways that control the proliferation of intestinal epithelial cells.5x5Neurath, M.F. and Travis, S.P. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut. 2012;
61: 1619–1635
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Mucosal healing is essential for proper response to IBD therapy. Anti–tumor necrosis factor (TNF) agents have drastically changed the way to treat IBD, leading to mucosal healing in IBD patients.39x39Neurath, M. New targets for mucosal healing and therapy in inflammatory bowel diseases. Mucosal Immunol. 2014;
7: 6
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New treatments for IBD are needed because many patients do not respond to the clinically approved drugs.4x4Neurath, M.F. Current and emerging therapeutic targets for IBD. Nate Rev Gastroenterol Hepatol. 2017;
14: 269
Crossref | PubMed | Scopus (108)
| Google ScholarSee all References

In conclusion, we report the observation that CD74 is increased in inflamed tissue in patients with IBD, a disease that affects millions of people worldwide, and provide evidence using human studies, mouse models, and cellular models that CD74 signaling is essential for inflammation-driven repair. These results potentially can be leveraged to create new therapeutic opportunities to address the unmet medical needs for IBD patients.

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